ASHRAE Standard 15 specifies requirements for the safe design, construction, installation, and operation of refrigeration systems. The 2022 edition is the largest update ever and includes major changes to the use of non-A1 refrigerants, new overpressure protection, new piping requirements, updated volume and refrigerant charge limit calculations, refrigerant detector/detection and mitigation actions and more.

ASHRAE Standard 34 describes a shorthand way of naming refrigerants, and it assigns safety classifications and refrigerant concentration limits based on toxicity and flammability data. The 2022 edition of the standard adds safety designations for twenty new refrigerants, modernizes submission application requirements for new refrigerants, and is updated to capture flammability limits used for non-A1 refrigerant maximum charge calculations.